Artios Pharma is currently recruiting a Bioinformatics Scientist to join our expanding team. This is an excellent opportunity to join a world class research team in a dynamic, expanding biotech company based south of Cambridge, UK. Artios is focused on identifying and developing cancer treatments by exploiting novel targets within the DNA damage response (DDR), a scientific area of high expectation following the success of PARP inhibitors in the clinic.
The company is actively working on an exciting portfolio of unique DNA repair projects. We currently have two programmes in early phases of clinical development. These phase 1/2a studies are evaluating the small-molecule ATR inhibitor ART0380 and the first-in-class Pol -Theta inhibitor ART4215 in patients with advanced or metastatic solid tumours.
Outline of the role:
You will join a growing research team within this innovative and expanding company. Your primary responsibilities will be to support bioinformatics projects in the pre-clinical and discovery spaces (particularly CRISPR analyses) but can also include clinical and translational projects as required.
Responsibilities and Duties:
- Application of bioinformatic tools and techniques to answer scientific questions for cross-organisational efforts spanning discovery biology, translational and clinical domains.
- Primary, secondary and integrative analyses of internal and external CRISPR datasets using internal pipelines. Execute and develop data visualisation and reporting tools.
- Analysis of internal and external cell panel drug sensitivity screens; application of statistical and AI/ML methods to associate with molecular phenotypes.
- Testing, benchmarking and implementation of innovative bioinformatics techniques.
- Curation and management of internal and external data resources.
- PhD in bioinformatics/computational biology or equivalent experience. Masters candidates with extensive relevant experience will also be considered
- Significant experience in statistical programming, data manipulation, analysis, visualisation and reporting using R/Bioconductor
- Experience and familiarity with data from high throughput platforms such as next generation sequencing
- Ability to work independently in an organised and methodical fashion
- Understanding of genomic and other omic data generation
- Experience of working in command line environments
- Experience of working with cancer patient and/or cell line ‘omics data e.g. from TCGA, ICGC, DepMap
- Excellent communication and presentation skills
- Ability to work to deadlines
This is a permanent position, offering an attractive salary & benefits package. Appointment will be at Scientist level depending on experience. If you have the right background, then please apply by sending your CV with a covering letter quoting Ref 4263.
Please apply using the link below and ensure that you click ‘upload’ before you finish your application.
In order to comply with UK Employment Law, all applicants must have the Right to Work in the UK or if from the EU, subject to receiving a relevant Skilled Worker Visa to work in the UK.
Due to the high volume of applications we receive, if you do not hear from us we will not be inviting you to interview on this occasion.
The closing date is Tuesday 31st January.
No agencies, thank you.