Artios Pharma is currently recruiting a Target Validation Scientist to join our expanding team. This is an excellent opportunity to join a world class research team in a dynamic, expanding biotech company based south of Cambridge, UK. Artios is focused on identifying and developing cancer treatments by exploiting novel targets within the DNA damage response (DDR), a scientific area of high expectation following the success of PARP inhibitors in the clinic.
The company is actively working on an exciting portfolio of unique DNA repair projects. We currently have two programmes in early phases of clinical development. These phase 1/2a studies are evaluating the small-molecule ATR inhibitor ART0380 and the first-in-class Pol -Theta inhibitor ART4215 in patients with advanced or metastatic solid tumours.
Outline of the role
You will join a growing research team within this innovative and expanding company. Your primary responsibilities will be to support the DDR Biology team in contributing biological data to Artios’ early-stage drug discovery projects. You will use genetic, cell biological and pharmacological strategies to identify and validate therapeutic targets using cell-based systems and deliver high quality cell biological and mode of action data packages to understand target biology. You will also work in multi-disciplinary collaborations involving a high level of teamwork.
Responsibilities and Duties:
- Apply expertise in cell and molecular biology to run mechanistic cell biological studies to validate Artios’ novel targets
- Contribute biological data to Artios’ ongoing drug discovery projects
Qualifications and Experience:
- PhD or equivalent in a life science subject
- Minimum of three years’ experience working in a research environment
- Experience of in vitro pharmacology or drug discovery
- Experience working in an industrial setting will be a distinct advantage
Key Skills and Abilities
- Excellent skills in a broad range of cell and molecular biology techniques, including mammalian cell culture, viability assays, Western blotting and RNA interference
- Understanding of DNA damage response biology, DNA repair pathways and/or cancer biology
- High level of team working skills required
- Ability to work independently as well as part of a team in an organised and methodical fashion
- Ability to troubleshoot experiments independently
- Excellent communication and presentation skills
- Excellent attention to detail
- Keeping accurate laboratory records
- High level of IT literacy
- Flexible approach to change
- Expertise in fluorescence microscopy-based methods such as immunofluorescence
- Expertise in flow cytometry
- Experience of small molecule drug discovery
- Experience with stable cell line generation
This is a permanent position, offering an attractive salary & benefits package. Appointment will be at Scientist level depending on experience. If you have the right background, then please apply by sending your CV with a covering letter quoting Ref 4264.
Please apply using the link below and ensure that you click ‘upload’ before you finish your application.
In order to comply with UK Employment Law, all applicants must have the Right to Work in the UK or if from the EU, subject to receiving a relevant Skilled Worker Visa to work in the UK.
Due to the high volume of applications we receive, if you do not hear from us we will not be inviting you to interview on this occasion.
The closing date is Tuesday 31st January.
No agencies, thank you.