Artios Pharma is currently recruiting for a cell and molecular biologist. This is an excellent opportunity to join a world class research team in a new dynamic Biotech company based south of Cambridge, UK. Artios is focused on identifying and developing cancer treatments by exploiting novel targets within the DNA damage response (DDR), a scientific area of high expectation following the success of PARP inhibitors in the clinic. The company is actively building an exciting portfolio of unique DDR projects and has the ambitious aim to quickly translate these discoveries into the clinic.
We currently have two programmes in early phases of clinical development. These phase 1/2a studies are evaluating the small-molecule ATR inhibitor ART0380 and the first-in-class Pol Theta inhibitor ART4215 in patients with advanced or metastatic solid tumours.
Outline of the role
You will join the Radiation Biology team to identify and validate DNA damage response (DDR) targets and agents capable of modulating these targets, for use in combination with radioligand therapies. Your primary responsibility will be performing functional studies to understand how modulating potential targets affect cellular response to radioligand therapy, applying cutting edge technologies such as CRISPR/Cas9 and immunofluorescent imaging. You will have the opportunity to work in multi-disciplinary collaborative networks, involving a large pharmaceutical company.
Appointment will be at the Scientist or Senior Scientist I level depending on experience.
Qualifications and Experience
- Proven track record of delivering excellent quality research
- PhD (or equivalent) in a life science subject
- Experience working in a research environment, ideally within an industrial setting
- Experience of in vitro pharmacology or drug discovery
- Experience working in industrial setting
Key Skills and Abilities
- Excellent skills in a broad range of cell and molecular biology techniques including cell culture, viability assays, Western blotting
- Good understanding of cancer cell biology, in particular as applied to therapeutic approaches
- Willingness to work with radioisotopes and other forms of radiation
- Ability to work independently in an organised and methodical fashion
- High level of team working skills required
- Enthusiasm and commitment to achieve within tight deadlines
- Excellent communication and presentation skills
- Excellent attention to detail and experimental record keeping
- High level of IT literacy
- Expertise in fluorescence microscopy-based methods such as immunofluorescence and in flow cytometry
- Expertise in CRISPR/Cas9 and sh/siRNA technologies
- Knowledge of DNA damage response and/or radiation biology
- Experience in working with radioisotopes
This is a permanent position, offering an attractive salary & benefits package. If you have the right background, then please apply on our website by uploading your CV with a covering letter quoting Ref 4275.
Please apply using the link below and ensure that you click ‘upload’ before you finish your application.
In order to comply with UK Employment Law, all applicants must have the Right to Work in the UK or if from the EU, subject to receiving a relevant Skilled Worker Visa to work in the UK.
Due to the high volume of applications we receive, if you do not hear from us we will not be inviting you to interview on this occasion.
No agencies, thank you.