Artios Pharma is currently recruiting a Translational Genomics Principal Scientist to join our expanding team. This is an excellent opportunity to join a world class research team in a dynamic, expanding biotech company based south of Cambridge, UK. Artios is focused on identifying and developing cancer treatments by exploiting novel targets within the DNA damage response (DDR), a scientific area of high expectation following the success of PARP inhibitors in the clinic.
The company is actively working on an exciting portfolio of unique DNA repair projects. We currently have two programmes in early phases of clinical development. These phase 1/2a studies are evaluating the small-molecule ATR inhibitor ART0380 and the first-in-class Pol -Theta inhibitor ART4215 in patients with advanced or metastatic solid tumours.
Outline of the role:
To provide high quality genomic biomarker expertise for Artios’s clinical programmes and ensure the timely implementation of novel technology in the field.
Responsibilities and Duties:
- Work with Translational Leads (TL’s) and Bioinformatics colleagues to oversee the implementation of genomic biomarker strategies in early phase clinical trials
- Act as the key contact for Artios with CRO’s to plan, procure and implement genomic technologies
- Perform evaluations of methods, platforms, new technologies and vendors for clinical genomic analysis
- Ensure all processes for the delivery of high quality genomic data are in place across projects
- Work with the translational and bioinformatics teams to support data QC/analysis/interpretation to report back to the project team
- Provide expert genomic advice for the development of companion diagnostics
- Work with the Director of Quality and TL’s to audit genomic vendors as required
- To keep up to date with clinical genomics technology and be the conduit of this for the company
- A PhD in Life Sciences or equivalent experience
- Highly experienced in working in a clinical/translational genomics environment preferably in Pharma or Biotech
- A thorough knowledge of handling and processing all types of tissues (i.e. FFPE, frozen, cfDNA, plasma) for DNA/RNA analysis from the clinic to data delivery
- Experience working with and managing studies with CRO’s/3rd party laboratories
- Expertise in cfDNA technology is strongly desired
- An understanding of the regulatory and quality frameworks required for clinical sample processing and analysis
- A sound knowledge of NGS technology available in the clinic and the related vendors
- Demonstration of peer reviewed publications in the field of clinical genomics
- High level of IT literacy
- Excellent communication and presentation skills
- Ability to work independently in an organised and methodical fashion
- Good interpersonal skills working at all levels with colleagues and external CRO’s
- Flexible approach to change
This is a permanent position, offering an attractive salary & benefits package. Appointment will be at Scientist level depending on experience. If you have the right background, then please apply by sending your CV with a covering letter quoting Ref 4265.
Please apply using the link below and ensure that you click ‘upload’ before you finish your application.
In order to comply with UK Employment Law, all applicants must have the Right to Work in the UK or if from the EU, subject to receiving a relevant Skilled Worker Visa to work in the UK.
Due to the high volume of applications we receive, if you do not hear from us we will not be inviting you to interview on this occasion.
The closing date is Tuesday 31st January.
No agencies, thank you.